High-throughput mRNA-seq atlas of human placenta shows vast transcriptome remodeling from first to third trimester†.

ABSTRACT: The placenta, composed of chorionic villi, changes dramatically across gestation. Understanding differences in ongoing pregnancies are essential to identify the role of chorionic villi at specific times in gestation and develop biomarkers and prognostic indicators of maternal-fetal health. The normative mRNA profile is established using next-generation sequencing of 124 first trimester and 43 third trimester human placentas from ongoing healthy pregnancies. Stably expressed genes (SEGs) not different between trimesters and with low variability are identified. Differential expression analysis of first versus third trimester adjusted for fetal sex is performed, followed by a subanalysis with 23 matched pregnancies to control for subject variability using the same genetic and environmental ba

SUBMITTER: Gonzalez TL 

PROVIDER: S-EPMC11094392 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature