Multiple primary tumors in patients with surgically treated pancreatic cancer: a SEER population-based study.

ABSTRACT:

Background

With improving survival after pancreatic cancer (PC) resection, questions emerge concerning risk and patterns of metachronous tumors. We aimed to determine the incidence of multiple primary cancers among postoperative PC survivors.

Methods

Patients undergoing PC surgery from 1975 to 2020 were identified in the Surveillance, Epidemiology, and End Results (SEER) registry. Standardized incidence ratios (SIRs) compared observed-to-expected cancers based on U.S. population rates. Cumulative incidence of secondary tumors was analyzed with Cox regression and cancer-specific survival with Kaplan-Meier curves.

Results

Of 6,100 resected PC patients, 267 (4.38%) developed multiple cancers over 6.2 years median follow-up period. Subsequent malignancies showed a rising

SUBMITTER: Zhang M 

PROVIDER: S-EPMC11094503 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature