Long acting progestogens versus combined oral contraceptive pill for preventing recurrence of endometriosis related pain: the PRE-EMPT pragmatic, parallel group, open label, randomised controlled trial.

ABSTRACT:

Objectives

To evaluate the clinical effectiveness of long acting progestogens compared with the combined oral contraceptive pill in preventing recurrence of endometriosis related pain.

Design

The PRE-EMPT (preventing recurrence of endometriosis) pragmatic, parallel group, open label, randomised controlled trial.

Setting

34 UK hospitals.

Participants

405 women of reproductive age undergoing conservative surgery for endometriosis.

Interventions

Participants were randomised in a 1:1 ratio using a secure internet facility to a long acting progestogen (depot medroxyprogesterone acetate or levonorgestrel releasing intrauterine system) or the combined oral contraceptive pill.

Main outcome measures

The primary outcome was pain measured three years after r

SUBMITTER: Cooper KG 

PROVIDER: S-EPMC11094611 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature