Genetically determined gut microbiota associates with pulmonary arterial hypertension: a Mendelian randomization study.

ABSTRACT:

Background

Emerging evidences have demonstrated that gut microbiota composition is associated with pulmonary arterial hypertension (PAH). However, the underlying causality between intestinal dysbiosis and PAH remains unresolved.

Method

An analysis using the two-sample Mendelian randomization (MR) approach was conducted to examine the potential causal relationship between gut microbiota and PAH. To assess exposure data, genetic variants associated with 196 bacterial traits were extracted from the MiBioGen consortium, which included a sample size of 18,340 individuals. As for the outcomes, summary statistics for PAH were obtained from the NHGRI-EBI GWAS Catalog, which conducted a meta-analysis of four independent studies comprising a total of 11,744 samples. Causal effects wer

SUBMITTER: Yuan Y 

PROVIDER: S-EPMC11094871 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature