Critical role of the gut microbiota in immune responses and cancer immunotherapy.

ABSTRACT: The gut microbiota plays a critical role in the progression of human diseases, especially cancer. In recent decades, there has been accumulating evidence of the connections between the gut microbiota and cancer immunotherapy. Therefore, understanding the functional role of the gut microbiota in regulating immune responses to cancer immunotherapy is crucial for developing precision medicine. In this review, we extract insights from state-of-the-art research to decipher the complicated crosstalk among the gut microbiota, the systemic immune system, and immunotherapy in the context of cancer. Additionally, as the gut microbiota can account for immune-related adverse events, we discuss potential interventions to minimize these adverse effects and discuss the clinical application of five microb

SUBMITTER: Li Z 

PROVIDER: S-EPMC11094969 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature