Distinct spatial contributions of amyloid pathology and cerebral small vessel disease to hippocampal morphology.

ABSTRACT:

Introduction

Cerebral small vessel disease (SVD) and amyloid beta (Aβ) pathology frequently co-exist. The impact of concurrent pathology on the pattern of hippocampal atrophy, a key substrate of memory impacted early and extensively in dementia, remains poorly understood.

Methods

In a unique cohort of mixed Alzheimer's disease and moderate-severe SVD, we examined whether total and regional neuroimaging measures of SVD, white matter hyperintensities (WMH), and Aβ, as assessed by ¹⁸F-AV45 positron emission tomography, exert additive or synergistic effects on hippocampal volume and shape.

Results

Frontal WMH, occipital WMH, and Aβ were independently associated with smaller hippocampal volume. Frontal WMH had a spatially distinct impact on hippocampal shape rel

SUBMITTER: Xhima K 

PROVIDER: S-EPMC11095424 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature