Antidepressant use in relation to dementia risk, cognitive decline, and brain atrophy.

ABSTRACT:

Introduction

We aimed to assess the effect of antidepressant use on dementia risk, cognitive decline, and brain atrophy.

Methods

In this prospective cohort study, we included 5511 dementia-free participants (Mini-Mental State Examination [MMSE] > 25) of the Rotterdam study (57.5% women, mean age 70.6 years). Antidepressant use was extracted from pharmacy records from 1991 until baseline (2002-2008). Incident dementia was monitored from baseline until 2018, with repeated cognitive assessment and magnetic resonance imaging (MRI) every 4 years.

Results

Compared to never use, any antidepressant use was not associated with dementia risk (hazard ratio [HR] 1.14, 95% confidence interval [CI] 0.92-1.41), or with accelerated cognitive decline or atrophy of white and gray matte

SUBMITTER: Vom Hofe I 

PROVIDER: S-EPMC11095425 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature