Investigating reliable amyloid accumulation in Centiloids: Results from the AMYPAD Prognostic and Natural History Study.

ABSTRACT:

Introduction

To support clinical trial designs focused on early interventions, our study determined reliable early amyloid-β (Aβ) accumulation based on Centiloids (CL) in pre-dementia populations.

Methods

A total of 1032 participants from the Amyloid Imaging to Prevent Alzheimer's Disease-Prognostic and Natural History Study (AMYPAD-PNHS) and Insight46 who underwent [¹⁸F]flutemetamol, [¹⁸F]florbetaben or [¹⁸F]florbetapir amyloid-PET were included. A normative strategy was used to define reliable accumulation by estimating the 95^th percentile of longitudinal measurements in sub-populations (N_PNHS = 101/750, N_Insight46 = 35/382) expected to remain stable over time. The baseline CL threshold that optimally predic

SUBMITTER: Bollack A 

PROVIDER: S-EPMC11095430 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature