On the effect heterogeneity of established disease susceptibility loci for Alzheimer's disease across different genetic ancestries.

ABSTRACT:

Introduction

Genome-wide association studies have identified numerous disease susceptibility loci (DSLs) for Alzheimer's disease (AD). However, only a limited number of studies have investigated the dependence of the genetic effect size of established DSLs on genetic ancestry.

Methods

We utilized the whole genome sequencing data from the Alzheimer's Disease Sequencing Project (ADSP) including 35,569 participants. A total of 25,459 subjects in four distinct populations (African ancestry, non-Hispanic White, admixed Hispanic, and Asian) were analyzed.

Results

We found that nine DSLs showed significant heterogeneity across populations. Single nucleotide polymorphism (SNP) rs2075650 in translocase of outer mitochondrial membrane 40 (TOMM40) showed the largest heterogeneit

SUBMITTER: Lee S 

PROVIDER: S-EPMC11095441 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature