20-year depressive symptoms, dementia, and structural neuropathology in older women.

ABSTRACT:

Introduction

The course of depressive symptoms and dementia risk is unclear, as are potential structural neuropathological common causes.

Methods

Utilizing joint latent class mixture models, we identified longitudinal trajectories of annually assessed depressive symptoms and dementia risk over 21 years in 957 older women (baseline age 72.7 years old) from the Women's Health Initiative Memory Study. In a subsample of 569 women who underwent structural magnetic resonance imaging, we examined whether estimates of cerebrovascular disease and Alzheimer's disease (AD)-related neurodegeneration were associated with identified trajectories.

Results

Five trajectories of depressive symptoms and dementia risk were identified. Compared to women with minimal symptoms, women who re

SUBMITTER: Petkus AJ 

PROVIDER: S-EPMC11095467 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature