The shift in the fatty acid composition of the circulating lipidome in Alzheimer's disease.

ABSTRACT:

Introduction

Fatty acids (FAs) are the building blocks of complex lipids and signaling compounds; the role of the lipidome fatty acid profile (LFA) in AD progression remains unclear.

Methods

The LFA of plasma and cerebrospinal fluid (CSF) samples from 289 participants (103 AD patients, 92 MCI patients, and 94 controls) was determined by GC-FID. The MCI subjects were followed up for 58 ± 12.5 months.

Results

In controls, CSF has a more neuroprotective LFA than plasma. In CSF, a higher content of docosahexaenoic acid was associated with a reduced risk of MCI-to-AD progression. In plasma, higher oleic acid content was associated with lower risk of AD, MCI, and MCI-to-AD progression, whereas higher levels of vaccenic acid and docosahexaenoic acid were associated with grea

SUBMITTER: Dakterzada F 

PROVIDER: S-EPMC11095469 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature