Impact of Liver Fibrosis Severity on Oncological Prognosis in Hepatocellular Carcinoma.

ABSTRACT:

Introduction

Cirrhosis is deemed to be a contributing factor to the postoperative recurrence of hepatocellular carcinoma (HCC); however, the precise impact of liver fibrosis on both cancer-specific prognoses remains unclear. This investigation sought to elucidate the effect of liver fibrosis severity on the cancer-specific prognosis.

Methods

A total of 524 consecutive patients were included. Recurrence-free survival (RFS) and disease-specific survival (DSS) were compared according to fibrosis stage. Moreover, postoperative outcomes were subjected to analysis in cohorts of patients with F0 and F1-3, as well as in those with F1-3 and F4, who were carefully matched for background factors.

Results

The 5-year RFS exhibited a significantly worse outcome in the F4 group comp

SUBMITTER: Yasukawa K 

PROVIDER: S-EPMC11095585 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature