Knocking Out Sodium Glucose-Linked Transporter 5 Prevents Fructose-Induced Renal Oxidative Stress and Salt-Sensitive Hypertension.

ABSTRACT:

Background

A fructose high-salt (FHS) diet increases systolic blood pressure and Ang II (angiotensin II)-stimulated proximal tubule (PT) superoxide (O₂^-) production. These increases are prevented by scavenging O₂^- or an Ang II type 1 receptor antagonist. SGLT4 (sodium glucose-linked cotransporters 4) and SGLT5 are implicated in PT fructose reabsorption, but their roles in fructose-induced hypertension are unclear. We hypothesized that PT fructose reabsorption by SGLT5 initiates a genetic program enhancing Ang II-stimulated oxidative stress in males and females, thereby causing fructose-induced salt-sensitive hypertension.

Methods

We measured systolic blood pressure in male and female Sprague-Dawley (wild type [WT]), SGLT4 knockout

SUBMITTER: Forester BR 

PROVIDER: S-EPMC11096007 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature