Sleep pressure modulates single-neuron synapse number in zebrafish.

ABSTRACT: Sleep is a nearly universal behaviour with unclear functions¹. The synaptic homeostasis hypothesis proposes that sleep is required to renormalize the increases in synaptic number and strength that occur during wakefulness². Some studies examining either large neuronal populations³ or small patches of dendrites⁴ have found evidence consistent with the synaptic homeostasis hypothesis, but whether sleep merely functions as a permissive state or actively promotes synaptic downregulation at the scale of whole neurons is unclear. Here, by repeatedly imaging all excitatory synapses on single neurons across sleep-wake states of zebrafish larvae, we show that synapses are gained during periods of wake (either spontaneous or forced) and lost during sleep i

SUBMITTER: Suppermpool A 

PROVIDER: S-EPMC11096099 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature