Mechanism of single-stranded DNA annealing by RAD52-RPA complex.

ABSTRACT: RAD52 is important for the repair of DNA double-stranded breaks^1,2, mitotic DNA synthesis^3-5 and alternative telomere length maintenance^6,7. Central to these functions, RAD52 promotes the annealing of complementary single-stranded DNA (ssDNA)^8,9 and provides an alternative to BRCA2/RAD51-dependent homologous recombination repair¹⁰. Inactivation of RAD52 in homologous-recombination-deficient BRCA1- or BRCA2-defective cells is synthetically lethal^11,12, and aberrant expression of RAD52 is associated with poor cancer prognosis^13,14. As a consequence, RAD52 is an attractive therapeutic target against homologous-recombination-deficient breast, ovarian and prostate cancers^15-17. Here we describe the structure

SUBMITTER: Liang CC 

PROVIDER: S-EPMC11096129 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature