Membrane-bound chemoreception of bitter bile acids and peptides is mediated by the same subset of bitter taste receptors.

ABSTRACT: The vertebrate sense of taste allows rapid assessment of the nutritional quality and potential presence of harmful substances prior to ingestion. Among the five basic taste qualities, salty, sour, sweet, umami, and bitter, bitterness is associated with the presence of putative toxic substances and elicits rejection behaviors in a wide range of animals including humans. However, not all bitter substances are harmful, some are thought to be health-beneficial and nutritious. Among those compound classes that elicit a bitter taste although being non-toxic and partly even essential for humans are bitter peptides and L-amino acids. Using functional heterologous expression assays, we observed that the 5 dominant human bitter taste receptors responsive to bitter peptides and amino acids are activa

SUBMITTER: Schaefer S 

PROVIDER: S-EPMC11096235 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature