Intestinal microflora promotes Th2-mediated immunity through NLRP3 in damp and heat environments.

ABSTRACT:

Background

With the worsening of the greenhouse effect, the correlation between the damp-heat environment (DH) and the incidence of various diseases has gained increasing attention. Previous studies have demonstrated that DH can lead to intestinal disorders, enteritis, and an up-regulation of NOD-like receptor protein 3 (NLRP3). However, the mechanism of NLRP3 in this process remains unclear.

Methods

We established a DH animal model to observe the impact of a high temperature and humidity environment on the mice. We sequenced the 16S rRNA of mouse feces, and the RNA transcriptome of intestinal tissue, as well as the levels of cytokines including interferon (IFN)-γ and interleukin (IL)-4 in serum.

Results

Our results indicate that the intestinal macrophage infiltration

SUBMITTER: Luo Y 

PROVIDER: S-EPMC11096527 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature