Transforming Static Barrier Tissue Models into Dynamic Microphysiological Systems.

ABSTRACT: Microphysiological systems are miniaturized cell culture platforms used to mimic the structure and function of human tissues in a laboratory setting. However, these platforms have not gained widespread adoption in bioscience laboratories where open-well, membrane-based approaches serve as the gold standard for mimicking tissue barriers, despite lacking fluid flow capabilities. This issue can be primarily attributed to the incompatibility of existing microphysiological systems with standard protocols and tools developed for open-well systems. Here, we present a protocol for creating a reconfigurable membrane-based platform with an open-well structure, flow enhancement capability, and compatibility with conventional protocols. This system utilizes a magnetic assembly approach that enables re

SUBMITTER: Mansouri M 

PROVIDER: S-EPMC11096840 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature