Association Between Disease-Modifying Therapy and Information Processing Speed in Multiple Sclerosis.

ABSTRACT:

Background

Cognitive impairment (CI) is common in multiple sclerosis (MS). Processing speed (PS) is often affected, making it an ideal target for monitoring CI. This study aims to evaluate the association between disease-modifying therapy (DMT) use and intensity and longitudinal changes in Processing Speed Test (PST) scores for individuals with MS.

Methods

A retrospective analysis of individual PST scores at a single MS center was conducted. Individuals with 2 or more PST assessments were included. Scores on the PST were compared longitudinally between those who had been on a DMT for 2 or more years and those who had been off a DMT for 2 or more years and between those on high-efficacy DMTs and those on low-/moderate-efficacy DMTs. A linear regression model was approximated

SUBMITTER: Aboseif A 

PROVIDER: S-EPMC11096850 | biostudies-literature | 2024 May-Jun

REPOSITORIES: biostudies-literature