Lateral entorhinal cortex subpopulations represent experiential epochs surrounding reward.

ABSTRACT: During goal-directed navigation, 'what' information, describing the experiences occurring in periods surrounding a reward, can be combined with spatial 'where' information to guide behavior and form episodic memories. This integrative process likely occurs in the hippocampus, which receives spatial information from the medial entorhinal cortex; however, the source of the 'what' information is largely unknown. Here, we show that mouse lateral entorhinal cortex (LEC) represents key experiential epochs during reward-based navigation tasks. We discover separate populations of neurons that signal goal approach and goal departure and a third population signaling reward consumption. When reward location is moved, these populations immediately shift their respective representations of each experie

SUBMITTER: Issa JB 

PROVIDER: S-EPMC11097142 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature