Dysregulation of peripheral and intratumoral KLRG1⁺ CD8⁺T cells is associated with immune evasion in patients with non-small-cell lung cancer.

ABSTRACT:

Objectives

Killer cell lectin like receptor G1 (KLRG1) is identified as a co-inhibitory receptor for NK cells and antigen-experienced T cells. The role of KLRG1 in immune regulation in patients with non-small cell lung cancer (NSCLC) remains poorly understood.

Materials and methods

We measured the proportion and immune function of KLRG1⁺CD8⁺T cells derived from peripheral blood in patients with NSCLC by flow cytometry. Besides, using data from the gene expression profiles and single-cell sequencing, we explored the expression and immune role of KLRG1 in tumor tissues of patients with NSCLC. We further determined the prognostic value of KLRG1 in terms of overall survival (OS) in NSCLC patients.

Results

We found that the proportion of KLRG1^+</

SUBMITTER: Zeng J 

PROVIDER: S-EPMC11097332 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature