A novel conductive microtubule hydrogel for electrical stimulation of chronic wounds based on biological electrical wires.

ABSTRACT: Electrical stimulation (ES) is considered a promising therapy for chronic wounds via conductive dressing. However, the lack of a clinically suitable conductive dressing is a serious challenge. In this study, a suitable conductive biomaterial with favorable biocompatibility and conductivity was screened by means of an inherent structure derived from the body based on electrical conduction in vivo. Ions condensed around the surface of the microtubules (MTs) derived from the cell's cytoskeleton are allowed to flow in the presence of potential differences, effectively forming a network of biological electrical wires, which is essential to the bioelectrical communication of cells. We hypothesized that MT dressing could improve chronic wound healing via the conductivity of MTs applied by ES. We

SUBMITTER: Fan W 

PROVIDER: S-EPMC11097419 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature