Microbiota-derived 3-phenylpropionic acid promotes myotube hypertrophy by Foxo3/NAD⁺ signaling pathway.

ABSTRACT:

Background

Gut microbiota and their metabolites play a regulatory role in skeletal muscle growth and development, which be known as gut-muscle axis. 3-phenylpropionic acid (3-PPA), a metabolite produced by colonic microorganisms from phenylalanine in the gut, presents in large quantities in the blood circulation. But few study revealed its function in skeletal muscle development.

Results

Here, we demonstrated the beneficial effects of 3-PPA on muscle mass increase and myotubes hypertrophy both in vivo and vitro. Further, we discovered the 3-PPA effectively inhibited protein degradation and promoted protein acetylation in C2C12 and chick embryo primary skeletal muscle myotubes. Mechanistically, we supported that 3-PPA reduced NAD⁺ synthesis and subsequently suppres

SUBMITTER: Li P 

PROVIDER: S-EPMC11097579 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature