Hepatic steatosis induced by nicotine plus Coca-Cola™ is prevented by nicotinamide riboside (NR).

ABSTRACT:

Introduction

Cigarettes containing nicotine (Nic) are a risk factor for the development of cardiovascular and metabolic diseases. We reported that Nic delivered via injections or e-cigarette vapor led to hepatic steatosis in mice fed with a high-fat diet. High-fructose corn syrup (HFCS) is the main sweetener in sugar-sweetened beverages (SSBs) in the US. Increased consumption of SSBs with HFCS is associated with increased risks of non-alcoholic fatty liver disease (NAFLD). Nicotinamide riboside (NR) increases mitochondrial nicotinamide adenine dinucleotide (NAD⁺) and protects mice against hepatic steatosis. This study evaluated if Nic plus Coca-Cola^™ (Coke) with HFCS can cause hepatic steatosis and that can be protected by NR.

Methods

C57BL/6J mice rece

SUBMITTER: Rivera JC 

PROVIDER: S-EPMC11097688 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature