Body mass index and all-cause mortality in HUNT and UK biobank studies: revised non-linear Mendelian randomisation analyses.

ABSTRACT:

Objectives

To estimate the shape of the causal relationship between body mass index (BMI) and mortality risk in a Mendelian randomisation framework.

Design

Mendelian randomisation analyses of two prospective population-based cohorts.

Setting

Individuals of European ancestries living in Norway or the UK.

Participants

56 150 participants from the Trøndelag Health Study (HUNT) in Norway and 366 385 participants from UK Biobank recruited by postal invitation.

Outcomes

All-cause mortality and cause-specific mortality (cardiovascular, cancer, non-cardiovascular non-cancer).

Results

A previously published non-linear Mendelian randomisation analysis of these data using the residual stratification method suggested a J-shaped association between genetically

SUBMITTER: Burgess S 

PROVIDER: S-EPMC11097829 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature