The Integration of Top-down and Bottom-up Inputs to the Striatal Cholinergic Interneurons.

ABSTRACT:

Background

Cholinergic interneurons (ChIs) are important for learning and memory. They exhibit a multiphasic excitation-pause-rebound response to reward or sensory cues indicating a reward, believed to gate dopamine-dependent learning. Although ChIs receive extensive top-down inputs from the cortex and bottom-up inputs from the thalamus and midbrain, it is unclear which inputs are involved in the development of ChI multiphasic activity.

Methods

We used a single-unit recording of putative ChIs (pChIs) in response to cortical and visual stimulation to investigate how top-down and bottom-up inputs regulate the firing pattern of ChIs.

Results

We demonstrated that cortical stimulation strongly regulates pChIs, with the maximum firing rate occurring at the peak of the inver

SUBMITTER: Zhang YF 

PROVIDER: S-EPMC11097987 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature