Energetic cost of biosynthesis is a missing link between growth and longevity in mammals.

ABSTRACT: The comparative studies of aging have established a negative correlation between Gompertz postnatal growth constant and maximum lifespan across mammalian species, but the underlying physiological mechanism remains unclear. This study shows that the Gompertz growth constant can be decomposed into two energetic components, mass-specific metabolic rate and the energetic cost of biosynthesis, and that after controlling the former as a confounder, the negative correlation between growth constant and lifespan still exists due to a 100-fold variation in the latter, revealing that the energetic cost of biosynthesis is a link between growth and longevity in mammals. Previously, the energetic cost of biosynthesis has been thought to be a constant across species and therefore was not considered a con

SUBMITTER: Hou C 

PROVIDER: S-EPMC11098097 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature