Tumor-neutrophil cross talk orchestrates the tumor microenvironment to determine the bladder cancer progression.

ABSTRACT: The immune landscape of bladder cancer progression is not fully understood, and effective therapies are lacking in advanced bladder cancer. Here, we visualized that bladder cancer cells recruited neutrophils by secreting interleukin-8 (IL-8); in turn, neutrophils played dual functions in bladder cancer, including hepatocyte growth factor (HGF) release and CCL3^highPD-L1^high super-immunosuppressive subset formation. Mechanistically, c-Fos was identified as the mediator of HGF up-regulating IL-8 transcription in bladder cancer cells, which was central to the positive feedback of neutrophil recruitment. Clinically, compared with serum IL-8, urine IL-8 was a better biomarker for bladder cancer prognosis and clinical benefit of immune checkpoint blockade (ICB). Additionally

SUBMITTER: Jing W 

PROVIDER: S-EPMC11098120 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature