Prognostic significance of growth differentiation factor-15 across age in chronic heart failure.

ABSTRACT:

Aims

Growth differentiation factor-15 (GDF15), a cytokine in the transforming growth factor family, is up-regulated in stress and inflammatory conditions and is elevated in patients with heart failure (HF). However, the age-specific attributes and prognostic significance of GDF15 across age remain unknown in chronic HF (CHF).

Methods and results

Serum levels of GDF15 were examined in 942 hypertensive patients (median 68 years) with CHF from the SUPPORT trial across the four age groups [under 50 (n = 73), 51-59 (n = 158), 60-69 (n = 296), and 70-79 years (n = 415)] and in the continuous spectrum. Clinical correlates of GDF15 were explored using the classic stepwise and LASSO (least absolute shrinkage and selection operator) regression approaches. Interaction terms with age we

SUBMITTER: Teramoto K 

PROVIDER: S-EPMC11098632 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature