Prevalence and prognostic impact of bone disease in chronic heart failure with reduced ejection fraction.

ABSTRACT:

Aims

Chronic heart failure is associated with a bone-catabolic state and increases the risk of osteoporosis and fractures. Prospective studies investigating the clinical relevance of bone disease in heart failure are lacking. We aimed to assess the prevalence and prognostic impact of osteoporosis and vertebral fractures (VFs) in chronic heart failure with reduced ejection fraction (HFrEF).

Methods and results

Symptomatic outpatients with chronic heart failure and a previous diagnosis of overtly reduced left ventricular ejection fraction < 40% on stable, optimal HFrEF therapy and left ventricular ejection fraction < 50% at enrolment were included into a prospective single-centre study. Osteoporosis was determined with dual-energy X-ray absorptiometry and defined as a T-score 

SUBMITTER: Verheyen N 

PROVIDER: S-EPMC11098648 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature