Worldwide absence of canonical benzimidazole resistance-associated mutations within β-tubulin genes from Ascaris.

ABSTRACT:

Background

The giant roundworm Ascaris is an intestinal nematode, causing ascariasis by infecting humans and pigs worldwide. Recent estimates suggest that Ascaris infects over half a billion people, with chronic infections leading to reduced growth and cognitive ability. Ascariasis affects innumerable pigs worldwide and is known to reduce production yields via decreased growth and condemnation of livers. The predominant anthelminthic drugs used to treat ascariasis are the benzimidazoles. Benzimidazoles interact with β-tubulins and block their function, and several benzimidazole resistance-associated mutations have been described in the β-tubulins of ruminant nematodes. Recent research on ascarids has shown that these canonical benzimidazole resistance-associated mutations are likel

SUBMITTER: Jones BP 

PROVIDER: S-EPMC11098727 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature