Plecanatide Improves Abdominal Bloating and Bowel Symptoms of Irritable Bowel Syndrome with Constipation.

ABSTRACT:

Background

Bloating is a bothersome symptom in irritable bowel syndrome with constipation (IBS-C).

Aim

To evaluate plecanatide efficacy in patients with IBS-C stratified by bloating intensity.

Methods

Pooled phase 3 data (2 randomized, controlled IBS-C trials) from adults treated with plecanatide 3 mg or placebo for 12 weeks were analyzed. Patients were stratified post-hoc by baseline bloating severity (11-point scale: mild [≤ 5] and moderate-to-severe [> 5]). Assessments included change from baseline in bloating, abdominal pain, and complete spontaneous bowel movement (CSBM) frequency. Abdominal pain and bloating composite responders were defined as patients with ≥ 30% improvement from baseline in both bloating and abdominal pain at Week 12.

Results

At baselin

SUBMITTER: Brenner DM 

PROVIDER: S-EPMC11098865 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature