An innovative method to strengthen evidence for potential drug safety signals using Electronic Health Records.

ABSTRACT: Reports from spontaneous reporting systems (SRS) are hypothesis generating. Additional evidence such as more reports is required to determine whether the generated drug-event associations are in fact safety signals. However, underreporting of adverse drug reactions (ADRs) delays signal detection. Through the use of natural language processing, different sources of real-world data can be used to proactively collect additional evidence for potential safety signals. This study aims to explore the feasibility of using Electronic Health Records (EHRs) to identify additional cases based on initial indications from spontaneous ADR reports, with the goal of strengthening the evidence base for potential safety signals. For two confirmed and two potential signals generated by the SRS of the Netherla

SUBMITTER: Abedian Kalkhoran H 

PROVIDER: S-EPMC11098892 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature