The influence of chorioamnionitis on respiratory drive and spontaneous breathing of premature infants at birth: a narrative review.

ABSTRACT: Most very premature infants breathe at birth but require respiratory support in order to stimulate and support their breathing. A significant proportion of premature infants are affected by chorioamnionitis, defined as an umbrella term for antenatal inflammation of the foetal membranes and umbilical vessels. Chorioamnionitis produces inflammatory mediators that potentially depress the respiratory drive generated in the brainstem. Such respiratory depression could maintain itself by delaying lung aeration, hampering respiratory support at birth and putting infants at risk of hypoxic injury. This inflammatory-mediated respiratory depression may contribute to an association between chorioamnionitis and increased requirement of neonatal resuscitation in premature infants at birth. This narrati

SUBMITTER: Panneflek TJR 

PROVIDER: S-EPMC11098929 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature