Pharmacogenomics, Race, and Treatment Outcome in Pediatric Acute Myeloid Leukemia.

ABSTRACT:

Importance

Disparities in outcomes exist between Black and White patients with acute myeloid leukemia (AML), with Black patients experiencing poorer prognosis compared with their White counterparts.

Objective

To assess whether varying intensity of induction therapy to treat pediatric AML is associated with reduced disparities in treatment outcome by race.

Design, setting, and participants

A comparative effectiveness analysis was conducted of 86 Black and 359 White patients with newly diagnosed AML who were enrolled in the AML02 trial from 2002 to 2008 or the AML08 trial from 2008 to 2017. Statistical analysis was conducted from July 2023 through January 2024.

Interventions

Patients in AML02 were randomly assigned to receive standard low-dose cytarabine-based in

SUBMITTER: Lamba JK 

PROVIDER: S-EPMC11099689 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature