Comparative study of the bronchodilator efficacy and adverse effects of salbutamol and hyoscine butylbromide in horses with severe asthma.

ABSTRACT:

Background

Salbutamol and hyoscine butylbromide (HBB) are commonly used bronchodilators in horses with severe asthma (SA).

Objective

To compare the bronchodilation potency, duration, and adverse effects of salbutamol and HBB in SA.

Animals

Six horses in exacerbation of SA.

Methods

The effects of inhaled salbutamol (1000 μg) and HBB (150 mg, IV) were compared in a randomized, blinded, crossover experiment. Lung function, intestinal borborygmi and heart rate were assessed before and sequentially until 180 minutes after drug administration, and analyzed with 2-way repeated-measures ANOVA and Dunnett's multiple comparison tests.

Results

Both treatments caused a similar improvement in lung function. Pulmonary resistance and reactance returned to baseline valu

SUBMITTER: Mozo Vives B 

PROVIDER: S-EPMC11099713 | biostudies-literature | 2024 May-Jun

REPOSITORIES: biostudies-literature