On the integration of decision trees with mixture cure model.

ABSTRACT: The mixture cure model is widely used to analyze survival data in the presence of a cured subgroup. Standard logistic regression-based approaches to model the incidence may lead to poor predictive accuracy of cure, specifically when the covariate effect is non-linear. Supervised machine learning techniques can be used as a better classifier than the logistic regression due to their ability to capture non-linear patterns in the data. However, the problem of interpret-ability hangs in the balance due to the trade-off between interpret-ability and predictive accuracy. We propose a new mixture cure model where the incidence part is modeled using a decision tree-based classifier and the proportional hazards structure for the latency part is preserved. The proposed model is very easy to interpre

SUBMITTER: Aselisewine W 

PROVIDER: S-EPMC11099950 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature