Dysregulated intestinal nutrient absorption in obesity is associated with epigenomic alterations in epithelia.

ABSTRACT: Obesity is an epidemic with myriad health effects, but little is understood regarding individual obese phenotypes and how they may respond to therapy. Epigenetic changes associated with obesity have been detected in blood, liver, pancreas, and adipose tissues. Previous work using human organoids found that dietary glucose hyperabsorption is a steadfast trait in cultures derived from some obese subjects, but detailed transcriptional or epigenomic features of the intestinal epithelia associated with this persistent phenotype are unknown. This study evaluated differentially expressed genes and relative chromatin accessibility in intestinal organoids established from donors classified as non-obese, obese, or obese hyperabsorptive by body mass index and glucose transport assays. Transcriptomic

SUBMITTER: Badurdeen DS 

PROVIDER: S-EPMC11100618 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature