Clinicogenomic characterization of inflammatory breast cancer.

ABSTRACT:

Background

Inflammatory breast cancer (IBC) is a rare and poorly characterized type of breast cancer with an aggressive clinical presentation. The biological mechanisms driving the IBC phenotype are relatively undefined-partially due to a lack of comprehensive, large-scale genomic studies and limited clinical cohorts.

Patients and methods

A retrospective analysis of 2457 patients with metastatic breast cancer who underwent targeted tumor-only DNA-sequencing was performed at Dana-Farber Cancer Institute. Clinicopathologic, single nucleotide variant (SNV), copy number variant (CNV) and tumor mutational burden (TMB) comparisons were made between clinically confirmed IBC cases within a dedicated IBC center versus non-IBC cases.

Results

Clinicopathologic differences betwee

SUBMITTER: Priedigkeit N 

PROVIDER: S-EPMC11100693 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature