Transcriptional repression and enhancer decommissioning silence cell cycle genes in postmitotic tissues.

ABSTRACT: The mechanisms that maintain a non-cycling status in postmitotic tissues are not well understood. Many cell cycle genes have promoters and enhancers that remain accessible even when cells are terminally differentiated and in a non-cycling state, suggesting their repression must be maintained long term. In contrast, enhancer decommissioning has been observed for rate-limiting cell cycle genes in the Drosophila wing, a tissue where the cells die soon after eclosion, but it has been unclear if this also occurs in other contexts of terminal differentiation. In this study, we show that enhancer decommissioning also occurs at specific, rate-limiting cell cycle genes in the long-lived tissues of the Drosophila eye and brain, and we propose this loss of chromatin accessibility may he

SUBMITTER: Fogarty EA 

PROVIDER: S-EPMC11100713 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature