Alternative splicing of clock transcript mediates the response of circadian clocks to temperature changes.

ABSTRACT: Circadian clocks respond to temperature changes over the calendar year, allowing organisms to adjust their daily biological rhythms to optimize health and fitness. In Drosophila, seasonal adaptations and temperature compensation are regulated by temperature-sensitive alternative splicing (AS) of period (per) and timeless (tim) genes that encode key transcriptional repressors of clock gene expression. Although clock (clk) gene encodes the critical activator of clock gene expression, AS of its transcripts and its potential role in temperature regulation of clock function have not been explored. We therefore sought to investigate whether clk exhibits AS in response to temperature and the functional changes of the differentially spliced t

SUBMITTER: Cai YD 

PROVIDER: S-EPMC11100826 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature