Associations Between Prenatal Vitamin D and Placental Gene Expression.

ABSTRACT:

Background

Vitamin D is a hormone regulating gene transcription. Prenatal vitamin D has been linked to immune and vascular function in the placenta, a key organ of pregnancy. To date, studies of vitamin D and placental gene expression have focused on a limited number of candidate genes. Transcriptome-wide RNA sequencing can provide a more complete representation of the placental effects of vitamin D.

Objective

We investigated the association between prenatal vitamin D levels and placental gene expression in a large, prospective pregnancy cohort.

Methods

Participants were recruited in Shelby County, Tennessee in the Conditions Affecting Neurocognitive Development and Learning in Early childhood (CANDLE) study. Vitamin D level (plasma total 25-hydroxyvitatmin D, [25(OH)

SUBMITTER: Parenti M 

PROVIDER: S-EPMC11100832 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature