Functional brain network dynamics of brooding in depression: insights from real-time fMRI neurofeedback.

ABSTRACT:

Background

Brooding is a critical symptom and prognostic factor of major depressive disorder (MDD), which involves passively dwelling on self-referential dysphoria and related abstractions. The neurobiology of brooding remains under characterized. We aimed to elucidate neural dynamics underlying brooding, and explore their responses to neurofeedback intervention in MDD.

Methods

We investigated functional MRI (fMRI) dynamic functional network connectivity (dFNC) in 36 MDD subjects and 26 healthy controls (HCs) during rest and brooding. Rest was measured before and after fMRI neurofeedback (MDD-active/sham: n=18/18, HC-active/sham: n=13/13). Baseline brooding severity was recorded using Ruminative Response Scale - Brooding subscale (RRS-B).

Results

Four recurrent dFNC s

SUBMITTER: Ganesan S 

PROVIDER: S-EPMC11100839 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature