Promoter recruitment drives the emergence of proto-genes in a long-term evolution experiment with Escherichia coli.

ABSTRACT: The phenomenon of de novo gene birth-the emergence of genes from non-genic sequences-has received considerable attention due to the widespread occurrence of genes that are unique to particular species or genomes. Most instances of de novo gene birth have been recognized through comparative analyses of genome sequences in eukaryotes, despite the abundance of novel, lineage-specific genes in bacteria and the relative ease with which bacteria can be studied in an experimental context. Here, we explore the genetic record of the Escherichia coli long-term evolution experiment (LTEE) for changes indicative of "proto-genic" phases of new gene birth in which non-genic sequences evolve stable transcription and/or translation. Over the time span of the LTEE, non-genic regions are frequently transcri

SUBMITTER: Uz-Zaman MH 

PROVIDER: S-EPMC11101190 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature