Weight change and all-cause and cause-specific mortality: A 25-year follow-up study.

ABSTRACT:

Background

Whether the dynamic weight change is an independent risk factor for mortality remains controversial. This study aimed to examine the association between weight change and risk of all-cause and cause-specific mortality based on the Linxian Nutrition Intervention Trial (NIT) cohort.

Methods

Body weight of 21,028 healthy residents of Linxian, Henan province, aged 40-69 years was measured two times from 1986 to 1991. Outcome events were prospectively collected up to 2016. Weight maintenance group (weight change <2 kg) or stable normal weight group was treated as the reference. Cox proportional hazard model was performed to calculate hazard ratios (HRs) and 95% confidence intervals (95% CIs) to estimate the risk of mortality.

Results

A total of 21,028 subjects w

SUBMITTER: Yang H 

PROVIDER: S-EPMC11101236 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature