Dummy run for planning of isotoxic dose-escalated radiation therapy for glioblastoma used in the PRIDE trial (NOA-28; ARO-2024-01; AG-NRO-06).

ABSTRACT:

Background

The PRIDE trial (NOA-28; ARO-2024-01; AG-NRO-06; NCT05871021) is designed to determine whether a dose escalation with 75.0 Gy in 30 fractions can enhance the median overall survival (OS) in patients with methylguanine methyltransferase (MGMT) promotor unmethylated glioblastoma compared to historical median OS rates, while being isotoxic to historical cohorts through the addition of concurrent bevacizumab (BEV). To ensure protocol-compliant irradiation planning with all study centers, a dummy run was planned and the plan quality was evaluated.

Methods

A suitable patient case was selected and the computed tomography (CT), magnetic resonance imaging (MRI) and O-(2-[¹⁸F]fluoroethyl)-L-tyrosine (FET) positron emission tomography (PET) contours were made avai

SUBMITTER: Maier SH 

PROVIDER: S-EPMC11101689 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature