Ventilatory Assistance Before Umbilical Cord Clamping in Extremely Preterm Infants: A Randomized Clinical Trial.

ABSTRACT:

Importance

Providing assisted ventilation during delayed umbilical cord clamping may improve outcomes for extremely preterm infants.

Objective

To determine whether assisted ventilation in extremely preterm infants (23 0/7 to 28 6/7 weeks' gestational age [GA]) followed by cord clamping reduces intraventricular hemorrhage (IVH) or early death.

Design, setting, and participants

This phase 3, 1:1, parallel-stratified randomized clinical trial conducted at 12 perinatal centers across the US and Canada from September 2, 2016, through February 21, 2023, assessed IVH and early death outcomes of extremely preterm infants randomized to receive 120 seconds of assisted ventilation followed by cord clamping vs delayed cord clamping for 30 to 60 seconds with ventilatory assistance

SUBMITTER: Fairchild KD 

PROVIDER: S-EPMC11102017 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature