Iron Is Critical for Mucosal-Associated Invariant T Cell Metabolism and Effector Functions.

ABSTRACT: Mucosal-Associated Invariant T (MAIT) cells are a population of innate T cells that play a critical role in host protection against bacterial and viral pathogens. Upon activation, MAIT cells can rapidly respond via both TCR-dependent and -independent mechanisms, resulting in robust cytokine production. The metabolic and nutritional requirements for optimal MAIT cell effector responses are still emerging. Iron is an important micronutrient and is essential for cellular fitness, in particular cellular metabolism. Iron is also critical for many pathogenic microbes, including those that activate MAIT cells. However, iron has not been investigated with respect to MAIT cell metabolic or functional responses. In this study, we show that human MAIT cells require exogenous iron, transported via CD7

SUBMITTER: Ryan EK 

PROVIDER: S-EPMC11102027 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature