Puerarin Alleviates Experimental Autoimmune Thyroiditis by Regulating Macrophages.

ABSTRACT: Hashimoto's thyroiditis (HT) is the most common organ-specific autoimmune disease, predominantly affecting women. Although the pathogenesis of HT is incompletely understood, some studies have found that macrophage polarization plays a role. Puerarin is a soy isoflavone compound that has anti-inflammatory and immunomodulatory effects and regulates macrophage immune activity. This study aimed to verify the therapeutic effect of puerarin on HT and explored its regulatory effect on macrophage polarization imbalance in HT. Through bioinformatics analysis and molecular biology methods, it was found that macrophages increased significantly in HT patients and model mice. Immunological staining showed that puerarin intervention could reduce tissue inflammatory cell infiltration. Molecular biologica

SUBMITTER: Tao Q 

PROVIDER: S-EPMC11102028 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature