Nitrogen starvation causes lipid remodeling in Rhodotorula toruloides.

ABSTRACT:

Background

The oleaginous yeast Rhodotorula toruloides is a promising chassis organism for the biomanufacturing of value-added bioproducts. It can accumulate lipids at a high fraction of biomass. However, metabolic engineering efforts in this organism have progressed at a slower pace than those in more extensively studied yeasts. Few studies have investigated the lipid accumulation phenotype exhibited by R. toruloides under nitrogen limitation conditions. Consequently, there have been only a few studies exploiting the lipid metabolism for higher product titers.

Results

We performed a multi-omic investigation of the lipid accumulation phenotype under nitrogen limitation. Specifically, we performed comparative transcriptomic and lipidomic analysis of the oleaginous yeast under

SUBMITTER: Mishra S 

PROVIDER: S-EPMC11102182 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature